Brain proteome-wide association study
WebMar 16, 2024 · Wingo TS, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, et al. Brain proteome-wide association study implicates novel proteins in depression pathogenesis. Nat Neurosci. 2024;24:810–7. WebDepression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide …
Brain proteome-wide association study
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WebDec 1, 2024 · Background: Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of … WebHow genome-wide associated loci confer risk for Parkinson's disease is unclear. To reveal causal risk genes through their effects on brain proteins to provide new pathogenesis insights for Parkinson's disease. Proteome-wide and transcriptome-wide associations were determined by functional summary-ba …
WebApr 3, 2024 · At the same time, genome-wide association studies (GWAS) have identified numerous common variants associated with brain structure. In this study, we integrate these findings, aiming to identify proteins, metabolites, or microbes that have a putative causal association with subcortical brain structure volumes via a two-sample Mendelian ... WebApr 12, 2024 · More information: Brain proteome-wide association study implicates novel proteins in depression pathogenesis, Nature Neuroscience (2024). DOI: 10.1038/s41593 …
WebApr 12, 2024 · To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = … We would like to show you a description here but the site won’t allow us. WebDec 7, 2024 · Utilizing a two-stage proteome-wide association study (PWAS) design, MS GWAS data (N = 41,505) was respectively integrated with two distinct human brain …
WebMethods: We systematically integrated lacunar stroke genome-wide association study (GWAS) (N=7338) with human brain proteomes (N=376) to perform proteome-wide association studies (PWAS), Mendelian randomization (MR), and Bayesian colocalization. We also used an independent human brain proteomic dataset (N=152) to annotate the …
WebApr 8, 2024 · Proteome-wide association study of cognitive trajectory and protein co-expression network analysis revealed that individuals with cognitive stability (i.e., relatively little decline in cognition ... townsfolk or townfolksWebIn contrast, a proteome-wide association study (PWAS) is a new method for detecting gene-phenotype associations mediated by protein function alterations. 28 Proteins are the final products of gene expression and the main functional components of cells, and thus are directly responsible for phenotype. PWAS could identify loci that confer sleep ... townsfolk tussle redditWebDec 6, 2024 · tudies, we first conducted a proteome-wide association study of alcohol dependence by integrating alcohol dependence genome-wide association studies with 2 human brain reference proteomes of dorsolateral prefrontal cortex from the Religious Order Study and Rush Memory and Aging Project and the Banner Sun Health Research … townsfolk traductiontownsfolk talk tripeWebApr 4, 2024 · Genetic control of body weight by the human brain proteome. Highlights. 25 genome-wide hits for body mass index (BMI) were mapped to brain proteins; 35 additional brain proteins were linked to BMI using Mendelian randomization; ... Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated … townsfolk tussle card sleeveWebDec 7, 2024 · Methods: Utilizing a two-stage proteome-wide association study (PWAS) design, MS GWAS data (N = 41,505) was respectively integrated with two distinct human brain proteomes from the dorsolateral prefrontal cortex, including ROSMAP (N = 376) in the discovery stage and Banner (N = 152) in the confirmation stage. In the following, … townsfolk terrariaWebtreatment-resistant schizophrenia proteome-wide association study human brain proteins lipid oxidation inflammation mitochondria. Type Research Article. Information European Psychiatry, Accepted manuscript, pp. 1 - 20. ... Based on a Proteome-wide Association Study. Wenming Wei (a1), ... townsfolk tussle reprint