WebHere, KpADH, an alcohol dehydrogenase from Kluyveromyces polyspora, exhibits evolutionary potential in the asymmetric reduction of N-Boc-3-piperidone (NBPO) to (S)-NBHP. By screening key residues in substrate binding pocket of Kp ADH, an excellent variant Y127W was obtained with 6-fold improved activity of 119.3 U mg −1 , 1.8-fold … Web16 de nov. de 2016 · (S)-N-Boc-3-hydroxypiperidine ((S)-NBHP) is a key pharmaceutical intermediate and the chiral source in synthesizing Imbruvica, which is a newly approved drug in lymphoma therapy by targeting Bruton’s tyrosine kinase (BTK). Current chemical synthesis of (S)-NBHP suffered from the need of noble metal catalyst and low yield. The …
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Web19 de abr. de 2024 · Asymmetric reduction of N-Boc-piperidin-3-one (NBPO) by reductases is a practical way to produce (S)-NBHP, since it can be carried out under mild reaction conditions, and results in high yield and remarkable enantioselectivity.However, only two cases of biocatalytic approaches were reported. The first practical process towards the … WebNotebook HP 15-DK1056WM 15.6" FHD IPS, Intel Core i5-10300H 2.5 / 4.5GHz, 8GB DDR4 256GB PCIe NVMe M.2 SSD, Video NVIDIA GeForce GTX 1650 4GB GDDR6, … hymer camper vans free 602
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